Open AccessDevelopmental window of vulnerability to white matter injury driven by sublethal intermittent hypoxemia
Author(s) -
Sergey A. Sosunov,
Zoya Niatsetskaya,
Анна Степанова,
Alexander Galkin,
Courtney Juliano,
Veniamin Ratner,
Vadim S. Ten
Publication year - 2021
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-021-01555-x
Subject(s) - white matter , phenotype , biology , hypoxemia , neuroscience , vulnerability (computing) , medicine , genetics , gene , magnetic resonance imaging , computer security , radiology , computer science
In the developing brain, the death of immature oligodendrocytes (OLs) has been proposed to explain a developmental window for vulnerability to white matter injury (WMI). However, in neonatal mice, chronic sublethal intermittent hypoxia (IH) recapitulates the phenotype of diffuse WMI without affecting cellular viability. This work determines whether, in neonatal mice, a developmental window of WMI vulnerability exists in the absence of OLs lineage cellular death.