Open AccessAngiopoietin-1 protects against endotoxin-induced neonatal lung injury and alveolar simplification in mice
Author(s) -
Umar Salimi,
Heather Menden,
Sherry M Mabry,
Xia Sheng,
Venkatesh Sampath
Publication year - 2021
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-021-01544-0
Subject(s) - lung , inflammation , medicine , sepsis , immunology , bronchopulmonary dysplasia , endothelial stem cell , biology , in vitro , pregnancy , biochemistry , genetics , gestational age
Sepsis in premature newborns is a risk factor for bronchopulmonary dysplasia (BPD), but underlying mechanisms of lung injury remain unclear. Aberrant expression of endothelial cell (EC) angiopoietin 2 (ANGPT2) disrupts angiopoietin 1 (ANGPT1)/TIE2-mediated endothelial quiescence, and is implicated in sepsis-induced acute respiratory distress syndrome in adults. We hypothesized that recombinant ANGPT1 will mitigate sepsis-induced ANGPT2 expression, inflammation, acute lung injury (ALI), and alveolar remodeling in the saccular lung.