Open AccessCalcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice
Author(s) -
Catherine Mayer,
B. Roos,
J.J. Teske,
Natalya Wells,
Richard J. Martin,
Wenhan Chang,
Christina M. Pabelick,
Y. S. Prakash,
Peter M. MacFarlane
Publication year - 2021
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-021-01540-4
Subject(s) - calcium sensing receptor , medicine , continuous positive airway pressure , fetus , airway , receptor , calcium in biology , calcium , endocrinology , anesthesia , calcium metabolism , pregnancy , biology , obstructive sleep apnea , genetics
Continuous positive airway pressure (CPAP) in preterm infants is initially beneficial, but animal models suggest longer term detrimental airway effects towards asthma. We used a neonatal CPAP mouse model and human fetal airway smooth muscle (ASM) to investigate the role of extracellular calcium-sensing receptor (CaSR) in these effects.