Open AccessDNA methylation in children with prenatal methamphetamine exposure and environmental adversity
Author(s) -
Oluwadamilola O Oni-Orisan,
Lynne M. Dansereau,
Carmen J. Marsit,
Lynne M. Smith,
Charles R. Neal,
Sheri A Della Grotta,
Jamés F. Padbury,
Barry M. Lester
Publication year - 2020
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-020-1058-4
Subject(s) - dna methylation , epigenetics , medicine , methylation , pregnancy , methamphetamine , cpg site , meconium , physiology , fetus , genetics , biology , psychiatry , gene , gene expression
Methamphetamine (MA) use during pregnancy is a significant public health concern in the United States and affects long-term brain and behavioral development in children. We hypothesized that prenatal MA exposure would be related to greater DNA methylation of HSD11B2 and postnatal environmental stress.