Open AccessImpairment in neurocognitive function following experimental neonatal guinea pig cytomegalovirus infection
Author(s) -
Claudia Fernández-Alarcón,
Lucy E. Meyer,
Michael A. McVoy,
James R. Lokensgard,
Shuxian Hu,
Michael A. Benneyworth,
Kaitlyn M. Anderholm,
Bradley C. Janus,
Mark R. Schleiss
Publication year - 2020
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-020-1010-7
Subject(s) - neurocognitive , cytomegalovirus , medicine , cytomegalovirus infection , guinea pig , virology , immunology , biology , human cytomegalovirus , human immunodeficiency virus (hiv) , cognition , virus , psychiatry , herpesviridae , viral disease
Cytomegalovirus (CMV) is a leading infectious cause of neurologic deficits, both in the settings of congenital and perinatal infection, but few animal models exist to study neurodevelopmental outcomes. This study examined the impact of neonatal guinea pig CMV (GPCMV) infection on spatial learning and memory in a Morris water maze (MWM) model.