Open AccessMiR-29b is associated with perinatal inflammation in extremely preterm infants
Author(s) -
Leeann R. Pavlek,
Sundari Vudatala,
Christopher W. Bartlett,
Irina A. Buhimschi,
Catalin S. Buhimschi,
Lynette K. Rogers
Publication year - 2020
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-020-0943-1
Subject(s) - medicine , chorioamnionitis , inflammation , biomarker , haptoglobin , cord blood , gestational age , amniotic fluid , venous blood , obstetrics , fetus , pregnancy , gastroenterology , immunology , biology , biochemistry , genetics
Inflammation is strongly associated with premature birth and neonatal morbidities. Increases in infant haptoglobin, haptoglobin-related protein (Hp&HpRP), and interleukin-6 (IL-6) levels are indicators of intra-amniotic inflammation (IAI) and have been linked to poor neonatal outcomes. Inflammation causes epigenetic changes, specifically suppression of miR-29 expression. The current study sought to determine whether miR-29b levels in cord blood or neonatal venous blood are associated with IAI, identified by elevated IL-6 and Hp, and subsequent clinical morbidities in the infant.