Open AccessEffects of vitamin D supplementation on circulating concentrations of growth factors and immune-mediators in healthy women during pregnancy
Author(s) -
Aastha Khatiwada,
Bethany J. Wolf,
Jennifer K. Mulligan,
Judith Shary,
Martin Hewison,
John E. Baatz,
Danforth A. Newton,
Catherine Hawrylowicz,
Bruce W. Hollis,
Carol L. Wagner
Publication year - 2020
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-020-0885-7
Subject(s) - immune system , vitamin d and neurology , pregnancy , medicine , gestation , vitamin , vitamin d deficiency , endocrinology , immunology , biology , genetics
For the second aim of the Kellogg Foundation grant, this double-blind RCT investigated the impact of plasma vitamin D metabolite 25-hydroxyvitamin D (25(OH)D) on plasma immune-mediators during pregnancy. We hypothesized that higher 25(OH)D concentrations would associate with reduced pro-inflammatory and increased tolerogenic immune-mediator concentrations.