Open AccessDose of budesonide with surfactant affects lung and systemic inflammation after normal and injurious ventilation in preterm lambs
Author(s) -
Noah H. Hillman,
Leenah Abugisisa,
Emily Royse,
Erin L. Fee,
Matthew W. Kemp,
Boris W. Kramer,
Augusto F. Schmidt,
Fabrizio Salomone,
Michael Clarke,
Gabrielle C. Musk,
Alan H. Jobe
Publication year - 2020
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-020-0809-6
Subject(s) - bronchopulmonary dysplasia , budesonide , pulmonary surfactant , mechanical ventilation , ventilation (architecture) , medicine , lung , anesthesia , tidal volume , respiratory system , chemistry , biology , inhalation , gestational age , biochemistry , pregnancy , mechanical engineering , genetics , engineering
The addition of budesonide (Bud) 0.25 mg/kg to surfactant decreased the lung and systemic responses to mechanical ventilation in preterm sheep and the rates and severity of bronchopulmonary dysplasia (BPD) in preterm infants. We hypothesized that lower budesonide concentrations in surfactant will decrease injury while decreasing systemic corticosteroid exposure.