Open AccessEffects of Klotho supplementation on hyperoxia-induced renal injury in a rodent model of postnatal nephrogenesis
Author(s) -
Mohammed Farhan Ali,
Sunil Kumar Bathally Venkatarayappa,
Merline Benny,
Claudia Rojas,
Keyvan Yousefi,
Lina A. Shehadeh,
Shathiyah Kulandavelu,
Mayank Sharma,
Naimeh Da Silva,
Michael Freundlich,
Carolyn Abitbol,
Marissa DeFreitas,
Karen Young
Publication year - 2020
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-020-0803-z
Subject(s) - kidney , medicine , endocrinology , hyperoxia , klotho , perfusion , renal function , lung
Hyperoxia (HO) causes kidney injury in preterm infants; however, whether these effects are modifiable is unknown. We hypothesized that administration of exogenous soluble Klotho, a kidney-derived antioxidant, would attenuate HO-induced kidney injury during postnatal nephrogenesis in rats.