Open AccessIncreased rates of vesicoureteral reflux in mice from deletion of Dicer in the peri-Wolffian duct stroma
Author(s) -
Melissa Anslow,
Andrew J. Bodnar,
Débora M. Cerqueira,
Daniel Bushnell,
Brynn E Shrom,
Sunder SimsLucas,
Carlton M. Bates,
Jacqueline Ho
Publication year - 2020
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-020-0788-7
Subject(s) - mesonephric duct , ureteric bud , stroma , vesicoureteral reflux , ureter , urinary system , biology , duct (anatomy) , andrology , medicine , urology , kidney , pathology , endocrinology , kidney development , reflux , gene , immunohistochemistry , embryonic stem cell , disease , biochemistry
Vesicoureteral reflux (VUR), backflow of urine into the kidney, is associated with urinary tract infections and chronic kidney disease. Integrity of the vesicoureteral junction (VUJ), where reflux occurs, is determined largely by proper induction of the ureteric bud from the Wolffian duct. Induction is modulated by signals from the surrounding peri-Wolffian duct stroma. We evaluated whether miRNAs in the peri-Wolffian duct stroma are necessary for proper ureteric induction, VUJ formation, and suppression of VUR.