Open AccessCPAP protects against hyperoxia-induced increase in airway reactivity in neonatal mice
Author(s) -
Peter M. MacFarlane,
Catherine Mayer,
Anjum Jafri,
Christina M. Pabelick,
Y. S. Prakash,
Richard J. Martin
Publication year - 2020
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-020-01212-9
Subject(s) - hyperoxia , airway , medicine , anesthesia , continuous positive airway pressure , lung , obstructive sleep apnea
Oxygen and continuous positive airway pressure (CPAP) are primary modes of respiratory support for preterm infants. Animal models, however, have demonstrated adverse unintended effects of hyperoxia and CPAP on lung development. We investigate the effects of combined neonatal hyperoxia and CPAP exposure on airway function and morphology in mice.