Open AccessIndole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine
Author(s) -
Di Meng,
Eduardo Sommella,
Emanuela Salviati,
Pietro Campiglia,
Kriston Ganguli,
Karim Djebali,
Weishu Zhu,
W. Allan Walker
Publication year - 2020
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-019-0740-x
Subject(s) - bifidobacterium longum , necrotizing enterocolitis , metabolite , aryl hydrocarbon receptor , inflammation , probiotic , tryptophan , kynurenine , cytokine , biology , microbiology and biotechnology , immunology , pharmacology , bifidobacterium , medicine , biochemistry , transcription factor , bacteria , amino acid , lactobacillus , fermentation , genetics , gene
Necrotizing enterocolitis (NEC), a necrotic inflammation of the intestine, represents a major health problem in the very premature infant. Although prevention is difficult, the combination of ingestion of maternal-expressed breastmilk in conjunction with a probiotic provides the best protection. In this study, we establish a mechanism for breastmilk/probiotic protection.