Open AccessPHF10 subunit of PBAF complex mediates transcriptional activation by MYC
Author(s) -
Natalia Soshnikova,
E. V. Tatarskiy,
Victor V. Tatarskiy,
Natalia Klimenko,
Alexander А. Shtil,
Mikhail A. Nikiforov,
С. Г. Георгиева
Publication year - 2021
Publication title -
oncogene
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.395
H-Index - 342
eISSN - 1476-5594
pISSN - 0950-9232
DOI - 10.1038/s41388-021-01994-0
Subject(s) - biology , chromatin , chromatin remodeling , transcriptional regulation , transcription factor , protein subunit , promoter , gene , regulation of gene expression , transcription (linguistics) , chia pet , cell cycle , microbiology and biotechnology , genetics , cancer research , gene expression , linguistics , philosophy
The PBAF complex, a member of SWI/SNF family of chromatin remodelers, plays an essential role in transcriptional regulation. We revealed a disease progression associated elevation of PHF10 subunit of PBAF in clinical melanoma samples. In melanoma cell lines, PHF10 interacts with MYC and facilitates the recruitment of PBAF complex to target gene promoters, therefore, augmenting MYC transcriptional activation of genes involved in the cell cycle progression. Depletion of either PHF10 or MYC induced G1 accumulation and a senescence-like phenotype. Our data identify PHF10 as a pro-oncogenic mechanism and an essential novel link between chromatin remodeling and MYC-dependent gene transcription.