Open AccessADORA1-driven brain-sympathetic neuro-adipose connections control body weight and adipose lipid metabolism
Author(s) -
Jia Zhang,
Yanjun Hou,
Xue Du,
Dan Chen,
Guangzhi Sui,
Yong Qi,
Júlio Licinio,
Ma-Li Wong,
Yunlei Yang
Publication year - 2020
Publication title -
molecular psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.071
H-Index - 213
eISSN - 1476-5578
pISSN - 1359-4184
DOI - 10.1038/s41380-020-00908-y
Subject(s) - adipose tissue , lipolysis , endocrinology , adipogenesis , adipocyte , medicine , white adipose tissue , energy homeostasis , biology , signal transduction , lipid metabolism , thermogenesis , neuroscience , microbiology and biotechnology , obesity
It is essential to elucidate brain-adipocyte interactions in order to tackle obesity and its comorbidities, as the precise control of brain-adipose tissue cross-talk is crucial for energy and glucose homeostasis. Recent studies show that in the peripheral adipose tissue, adenosine induces adipogenesis through peripheral adenosine A 1 receptor (pADORA 1 ) signaling; however, it remains unclear whether systemic and adipose tissue metabolism would also be under the control of central (c) ADORA 1 signaling. Here, we use tissue-specific pharmacology and metabolic tools to clarify the roles of cADORA 1 signaling in energy and adipocyte physiology. We found that cADORA 1 signaling reduces body weight while also inducing adipose tissue lipolysis. cADORA 1 signaling also increases adipose tissue sympathetic norepinephrine content. In contrast, pADORA 1 signaling facilitates a high-fat diet-induced obesity (DIO). We propose here a novel mechanism in which cADORA 1 and pADORA 1 signaling hinder and aggravate DIO, respectively.