Open AccessTargeting RNA-binding proteins in acute and chronic leukemia
Author(s) -
Irina Elcheva,
Vladimir S. Spiegelman
Publication year - 2020
Publication title -
leukemia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.539
H-Index - 192
eISSN - 1476-5551
pISSN - 0887-6924
DOI - 10.1038/s41375-020-01066-4
Subject(s) - rna binding protein , translation (biology) , biology , rna , gene expression , rna processing , messenger rna , computational biology , leukemia , gene , regulation of gene expression , microbiology and biotechnology , genetics
RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant expression of alternatively spliced, modified, and stabilized mRNA transcripts is essential to self-renewal, proliferation, and adaptation to stress. In this review, we assess the impact of key families of RBPs in leukemogenesis, review progress in targeting those proteins with small molecules, and discuss how multilevel composition of posttranscriptional regulation of gene expression could be used for potential therapies in acute and chronic leukemia.