Open AccessValidation of in vivo toenail measurements of manganese and mercury using a portable X-ray fluorescence device
Author(s) -
Aaron J. Specht,
Xinxin Zhang,
Anna S. Young,
Vy T. Nguyen,
David C. Christiani,
Diana Ceballos,
Joseph G. Allen,
Jennifer Weuve,
Linda H. Nie,
Marc G. Weisskopf
Publication year - 2021
Publication title -
journal of exposure science and environmental epidemiology/journal of exposure science and environmental epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.155
H-Index - 92
eISSN - 1559-064X
pISSN - 1559-0631
DOI - 10.1038/s41370-021-00358-w
Subject(s) - mercury (programming language) , manganese , in vivo , chemistry , environmental chemistry , inductively coupled plasma mass spectrometry , mass spectrometry , chromatography , biology , microbiology and biotechnology , organic chemistry , computer science , programming language
Toenail metal concentrations can be used as an effective biomarker for exposure to environmental toxicants. Typically toenail clippings are measured ex vivo using inductively coupled plasma mass spectrometry (ICP-MS). X-ray fluorescence (XRF) toenail metal measurements done on intact toenails in vivo could be used as an alternative to alleviate some of the disadvantages of ICP-MS. In this study, we assessed the ability to use XRF to measure toenail metal concentrations in real-time without having to clip the toenails (i.e., in vivo) in two occupational settings for exposure assessment of manganese and mercury.