Open AccessQuantitative methods for metabolomic analyses evaluated in the Children’s Health Exposure Analysis Resource (CHEAR)
Author(s) -
Chear Metabolomics Analysis Team,
Matthew J. Mazzella,
Susan Sumner,
Shumei Gao,
Su Li,
Nancy Diao,
Golam Mostofa,
Qazi Qamruzzaman,
Wimal Pathmasiri,
David C. Christiani,
Timothy R. Fennell,
Chris Gennings
Publication year - 2019
Publication title -
journal of exposure science and environmental epidemiology/journal of exposure science and environmental epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.155
H-Index - 92
eISSN - 1559-064X
pISSN - 1559-0631
DOI - 10.1038/s41370-019-0162-1
Subject(s) - metabolomics , univariate , metabolome , confounding , population , lasso (programming language) , medicine , statistics , computer science , multivariate statistics , bioinformatics , biology , environmental health , mathematics , world wide web
With advances in technologies that facilitate metabolome-wide analyses, the incorporation of metabolomics in the pursuit of biomarkers of exposure and effect is rapidly evolving in population health studies. However, many analytic approaches are limited in their capacity to address high-dimensional metabolomics data within an epidemiologic framework, including the highly collinear nature of the metabolites and consideration of confounding variables. In this Children's Health Exposure Analysis Resource (CHEAR) network study, we showcase various analytic approaches that are established as well as novel in the field of metabolomics, including univariate single metabolite models, least absolute shrinkage and selection operator (LASSO), random forest, weighted quantile sum (WQS RS ) regression, exploratory factor analysis (EFA), and latent class analysis (LCA). Here, in a Bangladeshi birth cohort (n = 199), we illustrate research questions that can be addressed by each analytic method in the assessment of associations between cord blood metabolites ( 1 H NMR measurements) and birth anthropometric measurements (birth weight and head circumference).