Open AccessDNA methylation and adiposity phenotypes: an epigenome-wide association study among adults in the Strong Heart Study
Author(s) -
Katherine C. Crocker,
Arce DomingoRelloso,
Karin Haack,
Amanda M. Fretts,
Wan Yee Tang,
Miguel Herreros,
María Téllez-Plaza,
M. Daniele Fallin,
Shelley A. Cole,
AvasAcien
Publication year - 2020
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/s41366-020-0646-z
Subject(s) - waist , dna methylation , epigenome , epigenetics , cpg site , endocrinology , circumference , biology , medicine , genome wide association study , dnam , body mass index , physiology , methylation , genetics , gene , gene expression , single nucleotide polymorphism , genotype , geometry , mathematics
Elevated adiposity is often posited by medical and public health researchers to be a risk factor associated with cardiovascular disease, diabetes, and other diseases. These health challenges are now thought to be reflected in epigenetic modifications to DNA molecules, such as DNA methylation, which can alter gene expression.