Open AccessFetal macrosomia in a Hispanic/Latinx predominant cohort and altered expressions of genes related to placental lipid transport and metabolism
Author(s) -
Haiyan Yang,
Bin He,
Chandra Yallampalli,
Haijun Gao
Publication year - 2020
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/s41366-020-0610-y
Subject(s) - fetal macrosomia , gestational diabetes , fetus , endocrinology , medicine , pregnancy , lipid metabolism , obesity , obstetrics , gestational age , diabetes mellitus , gestation , biology , genetics
Fetal overgrowth, termed fetal macrosomia when birth weight is >4000 g, is the major concern in the treatment of gestational diabetes mellitus (GDM). However, to date, the underlying mechanisms of fetal macrosomia have not been understood completely. Placental lipid metabolism is emerging as a critical player in fetal growth. In this study, we hypothesized that fatty-acid transport and metabolism in the placental tissue is impaired in GDM women, dependent on fetal sex.