Open AccessPlacental DNA methylation changes associated with maternal prepregnancy BMI and gestational weight gain
Author(s) -
Deepika Shrestha,
Marion Ouidir,
Tsegaselassie Workalemahu,
Xuehuo Zeng,
Fasil TekolaAyele
Publication year - 2020
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/s41366-020-0546-2
Subject(s) - dna methylation , body mass index , offspring , epigenetics , pregnancy , placenta , methylation , obesity , endocrinology , epigenome , medicine , weight gain , fetus , biology , andrology , genetics , gene expression , gene , body weight
Maternal obesity prior to or during pregnancy influences fetal growth, predisposing the offspring to increased risk for obesity across the life course. Placental epigenetic mechanisms may underlie these associations. We conducted an epigenome-wide association study to identify placental DNA methylation changes associated with maternal prepregnancy body mass index (BMI) and rate of gestational weight gain at first (GWG1), second (GWG2), and third trimester (GWG3).