Open AccessA missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants
Author(s) -
Kendall Arslanian,
Ulai T. Fidow,
Theresa Atanoa,
Folla Unasa-Apelu,
Take Naseri,
Abigail Wetzel,
Alysa Pomer,
Rachel L. Duckham,
Stephen T. McGarvey,
Joshua A Strayer,
Erin E. Kershaw,
Daniel E. Weeks,
Nicola L. Hawley
Publication year - 2020
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/s41366-020-00659-4
Subject(s) - body mass index , medicine , anthropometry , overweight , obesity , minor allele frequency , lean body mass , odds ratio , population , missense mutation , endocrinology , prospective cohort study , physiology , allele , allele frequency , genetics , biology , body weight , environmental health , mutation , gene
In Samoa, where 80% of the adult population is living with obesity, understanding the determinants of adiposity and growth during infancy may inform prevention efforts. We examined the association of a missense variant, rs373863828, in the CREBRF gene with body composition in Samoan infants. Adults with one or more copies of the rs373863828 minor allele (A) have higher odds of obesity, based on body-mass index (BMI), but paradoxically decreased odds of diabetes compared to those without the allele. Our study may offer novel insight into the natural history and pathogenesis of this unexpected relationship.