Open AccessRevitalizing Personalized Medicine: Respecting Biomolecular Complexities Beyond Gene Expression
Author(s) -
Jayachandran D,
Ramkrishna U,
Skiles J,
Renbarger J,
Ramkrishna D
Publication year - 2014
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1038/psp.2014.6
Subject(s) - personalized medicine , computational biology , expression (computer science) , gene expression , gene , biology , data science , genetics , computer science , programming language
Despite recent advancements in “omic” technologies, personalized medicine has not realized its fullest potential due to isolated and incomplete application of gene expression tools. In many instances, pharmacogenomics is being interchangeably used for personalized medicine, when actually it is one of the many facets of personalized medicine. Herein, we highlight key issues that are hampering the advancement of personalized medicine and highlight emerging predictive tools that can serve as a decision support mechanism for physicians to personalize treatments. CPT Pharmacometrics Syst. Pharmacol . (2014) 3, e110; doi: 10.1038/psp.2014.6 ; published online 16 April 2014