Open AccessPredicting QTc Prolongation in Man From Only In Vitro Data
Author(s) -
Leishman DJ
Publication year - 2014
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1038/psp.2014.33
Subject(s) - prolongation , qt interval , in vitro , medicine , chemistry , biochemistry
Mishra et al . 1 in their article “Interaction between domperidone and ketoconazole: toward prediction of consequent QTc prolongation using purely in vitro information” describe the use of physiologically based pharmacokinetic (PBPK) modeling and pharmacodynamic models of cardiac repolarization to predict clinical data from preclinical data. Eliminating the risk of cardiac arrhythmias through delayed repolarization often relies on preclinical data during compound selection. Although there are some limitations, there appears to be significant promise in using this modeling approach. CPT Pharmacometrics Syst. Pharmacol . (2014) 3, e131; doi: 10.1038/psp.2014.33 ; published online 20 August 2014