Open AccessClinical Translation in the Virtual Liver Network
Author(s) -
Kuepfer L,
Kerb R,
Henney AM
Publication year - 2014
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1038/psp.2014.25
Subject(s) - pharmacokinetics , drug metabolism , drug , human liver , computer science , pharmacology , german , physiology , medicine , computational biology , bioinformatics , biology , biochemistry , history , archaeology , enzyme
The liver is the central detoxifying organ, continuously removing xenobiotics from the vascular system. Given its role in drug metabolism, a functional understanding of liver physiology is crucial to optimizing drug efficacy and patient safety. The Virtual Liver Network (VLN), a German national flagship research program, focuses on producing validated computer models of human liver physiology. These models are used to analyze patient‐derived data and thereby gain mechanistic insights in the processes underlying drug pharmacokinetics (PK). CPT Pharmacometrics Syst. Pharmacol . (2014) 3, e127; doi: 10.1038/psp.2014.25 ; published online 30 July 2014