Open AccessThe Future of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure in Pregnant Women
Author(s) -
Vinks AA
Publication year - 2013
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1038/psp.2013.9
Subject(s) - pharmacokinetics , drug , physiologically based pharmacokinetic modelling , pregnancy , medicine , pharmacology , disposition , clinical pharmacology , biology , psychology , social psychology , genetics
Pregnant women have long been orphaned from drug studies. The application of physiologically based pharmacokinetic modeling to quantitatively describe drug disposition and effects during pregnancy is an attractive approach that is now actively pursued as it allows optimal use of available information for both efficient study designs and prediction of maternal–fetal exposure. CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e33; doi: 10.1038/psp.2013.9 ; advance online publication 6 March 2013