Open AccessEvaluating Systems Pharmacology Models Is Different From Evaluating Standard Pharmacokinetic–Pharmacodynamic Models
Author(s) -
Agoram B
Publication year - 2014
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1038/psp.2013.77
Subject(s) - clinical pharmacology , systems pharmacology , molecular pharmacology , pharmacology , confusion , pharmacodynamics , computer science , pharmacokinetics , medicine , drug , psychology , receptor , psychoanalysis
Based on the author's recent experience, there appears to be some confusion regarding the steps required to qualify a systems pharmacology model as adequate for the intended purpose. This manuscript outlines the model evaluation approach used in the author's recent publication 1 on the systems pharmacology of a 5‐lipoxygenase inhibitor and is an attempt to generate discussion on this topic within the pharmacometrics and systems pharmacology community. CPT Pharmacometrics Syst. Pharmacol . (2014) 3, e101; doi: 10.1038/psp.2013.77 ; published online 19 February 2014