Evaluating Systems Pharmacology Models Is Different From Evaluating Standard Pharmacokinetic–Pharmacodynamic Models | Zendy

Agoram B | Zendy

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Evaluating Systems Pharmacology Models Is Different From Evaluating Standard Pharmacokinetic–Pharmacodynamic Models

Author(s) -

Agoram B

Publication year - 2014

Publication title -

cpt: pharmacometrics and systems pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.53

H-Index - 37

ISSN - 2163-8306

DOI - 10.1038/psp.2013.77

Subject(s) - clinical pharmacology , systems pharmacology , molecular pharmacology , pharmacology , confusion , pharmacodynamics , computer science , pharmacokinetics , medicine , drug , psychology , receptor , psychoanalysis

Based on the author's recent experience, there appears to be some confusion regarding the steps required to qualify a systems pharmacology model as adequate for the intended purpose. This manuscript outlines the model evaluation approach used in the author's recent publication 1 on the systems pharmacology of a 5‐lipoxygenase inhibitor and is an attempt to generate discussion on this topic within the pharmacometrics and systems pharmacology community. CPT Pharmacometrics Syst. Pharmacol . (2014) 3, e101; doi: 10.1038/psp.2013.77 ; published online 19 February 2014

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