Open AccessBasic Concepts in Population Modeling, Simulation, and Model‐Based Drug Development: Part 3—Introduction to Pharmacodynamic Modeling Methods
Author(s) -
Upton RN,
Mould DR
Publication year - 2014
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1038/psp.2013.71
Subject(s) - pharmacodynamics , computer science , population , drug development , drug , pharmacology , medicine , pharmacokinetics , environmental health
Population pharmacodynamic (PD) models describe the time course of drug effects, relating exposure to response, and providing a more robust understanding of drug action than single assessments. PD models can test alternative dose regimens through simulation, allowing for informed assessment of potential dose regimens and study designs. This is the third paper in a three‐part series, providing an introduction into methods for developing and evaluating population PD models. Example files are available in the Supplementary Data. CPT Pharmacometrics Syst. Pharmacol . (2014) 3, e88; doi: 10.1038/psp.2013.71 ; published online 2 January 2014