
AMGET, an R‐Based Postprocessing Tool for ADAPT 5
Author(s) -
Guiastrennec B,
Wollenberg L,
Forrest A,
AitOudhia S
Publication year - 2013
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1038/psp.2013.36
Subject(s) - computer science , personalization , nonmem , maximization , software , simple (philosophy) , population , feature (linguistics) , graphical user interface , data mining , machine learning , programming language , philosophy , linguistics , demography , epistemology , sociology , world wide web , economics , microeconomics
ADAPT 5 is a powerful modeling software for population pharmacokinetic and pharmacodynamic systems analysis, but provides limited built‐in functionality for creating pre‐ and post‐analysis diagnostic plots. ADAPT 5 Model Evaluation Graphical Toolkit (AMGET), an external package written in the open source R programming language, was developed specifically to support efficient postprocessing of ADAPT 5 runs, as well as NONMEM and S‐ADAPT runs. Using interactive navigational menus, users of AMGET are able to rapidly create informative diagnostic plots enriched by the display of numerical and graphical elements with a high degree of customization using a simple settings spreadsheet. This article describes each feature of the AMGET package and illustrates how it allows users to utilize the powerful numerical routines of the ADAPT 5 package in a more efficient manner through the use of a simulated dataset and a simple pharmacokinetic model optimized using the maximum likelihood expectation maximization (MLEM) algorithm of ADAPT 5. CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e61; doi: 10.1038/psp.2013.36 ; published online 31 July 2013