Establishing Best Practices and Guidance in Population Modeling: An Experience With an Internal Population Pharmacokinetic Analysis Guidance | Zendy

Byon W | Zendy; Smith MK | Zendy; Chan P | Zendy; Tortorici MA | Zendy; Riley S | Zendy; Dai H | Zendy; Dong J | Zendy; RuizGarcia A | Zendy; Sweeney K | Zendy; Cronenberger C | Zendy

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Establishing Best Practices and Guidance in Population Modeling: An Experience With an Internal Population Pharmacokinetic Analysis Guidance

Author(s) -

Byon W,

Smith MK,

Chan P,

Tortorici MA,

Riley S,

Dai H,

Dong J,

RuizGarcia A,

Sweeney K,

Cronenberger C

Publication year - 2013

Publication title -

cpt: pharmacometrics and systems pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.53

H-Index - 37

ISSN - 2163-8306

DOI - 10.1038/psp.2013.26

Subject(s) - workflow , consistency (knowledge bases) , population , computer science , pharmacokinetics , medicine , pharmacology , artificial intelligence , environmental health , database

This tutorial describes the development of a population pharmacokinetic (Pop PK) analysis guidance within Pfizer, which strives for improved consistency and efficiency, and a more systematic approach to model building. General recommendations from the Pfizer internal guidance and a suggested workflow for Pop PK model building are discussed. A description is also provided for mechanisms by which conflicting opinions were captured and resolved across the organization to arrive at the final guidance. CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e51; doi: 10.1038/psp.2013.26 ; advance online publication 3 July 2013

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