Open AccessEstablishing Best Practices and Guidance in Population Modeling: An Experience With an Internal Population Pharmacokinetic Analysis Guidance
Author(s) -
Byon W,
Smith MK,
Chan P,
Tortorici MA,
Riley S,
Dai H,
Dong J,
RuizGarcia A,
Sweeney K,
Cronenberger C
Publication year - 2013
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1038/psp.2013.26
Subject(s) - workflow , consistency (knowledge bases) , population , computer science , pharmacokinetics , medicine , pharmacology , artificial intelligence , environmental health , database
This tutorial describes the development of a population pharmacokinetic (Pop PK) analysis guidance within Pfizer, which strives for improved consistency and efficiency, and a more systematic approach to model building. General recommendations from the Pfizer internal guidance and a suggested workflow for Pop PK model building are discussed. A description is also provided for mechanisms by which conflicting opinions were captured and resolved across the organization to arrive at the final guidance. CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e51; doi: 10.1038/psp.2013.26 ; advance online publication 3 July 2013