White Paper: Landscape on Technical and Conceptual Requirements and Competence Framework in Drug/Disease Modeling and Simulation | Zendy

Vlasakakis G | Zendy; Comets E | Zendy; Keunecke A | Zendy; Gueorguieva I | Zendy; Magni P | Zendy; Terranova N | Zendy; Della Pasqua O | Zendy; Lange EC | Zendy; Kloft C | Zendy

Open Access

White Paper: Landscape on Technical and Conceptual Requirements and Competence Framework in Drug/Disease Modeling and Simulation

Author(s) -

Vlasakakis G,

Comets E,

Keunecke A,

Gueorguieva I,

Magni P,

Terranova N,

Della Pasqua O,

Lange EC,

Kloft C

Publication year - 2013

Publication title -

cpt: pharmacometrics and systems pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.53

H-Index - 37

ISSN - 2163-8306

DOI - 10.1038/psp.2013.16

Subject(s) - competence (human resources) , conceptual framework , computer science , management science , knowledge management , process management , pharmacology , medicine , engineering , psychology , sociology , social psychology , social science

Pharmaceutical sciences experts and regulators acknowledge that pharmaceutical development as well as drug usage requires more than scientific advancements to cope with current attrition rates/therapeutic failures. Drug disease modeling and simulation (DDM&S) creates a paradigm to enable an integrated and higher‐level understanding of drugs, (diseased)systems, and their interactions (systems pharmacology) through mathematical/statistical models (pharmacometrics) 1 —hence facilitating decision making during drug development and therapeutic usage of medicines. To identify gaps and challenges in DDM&S, an inventory of skills and competencies currently available in academia, industry, and clinical practice was obtained through survey. The survey outcomes revealed benefits, weaknesses, and hurdles for the implementation of DDM&S. In addition, the survey indicated that no consensus exists about the knowledge, skills, and attributes required to perform DDM&S activities effectively. Hence, a landscape of technical and conceptual requirements for DDM&S was identified and serves as a basis for developing a framework of competencies to guide future education and training in DDM&S. CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e40; doi: 10.1038/psp.2013.16 ; advance online publication 1 May 2013

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