Open AccessWhite Paper: Landscape on Technical and Conceptual Requirements and Competence Framework in Drug/Disease Modeling and Simulation
Author(s) -
Vlasakakis G,
Comets E,
Keunecke A,
Gueorguieva I,
Magni P,
Terranova N,
Della Pasqua O,
Lange EC,
Kloft C
Publication year - 2013
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1038/psp.2013.16
Subject(s) - competence (human resources) , conceptual framework , computer science , management science , knowledge management , process management , pharmacology , medicine , engineering , psychology , sociology , social psychology , social science
Pharmaceutical sciences experts and regulators acknowledge that pharmaceutical development as well as drug usage requires more than scientific advancements to cope with current attrition rates/therapeutic failures. Drug disease modeling and simulation (DDM&S) creates a paradigm to enable an integrated and higher‐level understanding of drugs, (diseased)systems, and their interactions (systems pharmacology) through mathematical/statistical models (pharmacometrics) 1 —hence facilitating decision making during drug development and therapeutic usage of medicines. To identify gaps and challenges in DDM&S, an inventory of skills and competencies currently available in academia, industry, and clinical practice was obtained through survey. The survey outcomes revealed benefits, weaknesses, and hurdles for the implementation of DDM&S. In addition, the survey indicated that no consensus exists about the knowledge, skills, and attributes required to perform DDM&S activities effectively. Hence, a landscape of technical and conceptual requirements for DDM&S was identified and serves as a basis for developing a framework of competencies to guide future education and training in DDM&S. CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e40; doi: 10.1038/psp.2013.16 ; advance online publication 1 May 2013