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MONW Phenotype Is Associated With Advanced Colorectal Adenoma in Korean Men
Author(s) -
Kim MoonChan,
Kim ChangSup,
Chung TaeHeum,
Jeong Joseph,
Lee SeonHo,
Kim SungRyul,
Jung SeokWon,
Park NeungHwa,
Yoo CheolIn
Publication year - 2012
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2011.34
Subject(s) - medicine , odds ratio , waist , confidence interval , adenoma , colorectal adenoma , metabolic syndrome , colorectal cancer , endocrinology , body mass index , oncology , obesity , cancer
The aim of this study was to investigate whether there was a relationship between colorectal adenoma and metabolically obese but normal weight (MONW) among Korean men and women. The MONW phenotype is defined as a BMI <25, but fulfilling the metabolic syndrome (MS) criteria with a modified waist circumference (≥90 cm for men and ≥85 cm for women) appropriate for Korean. A total of 3,430 subjects (2,263 men and 1,167 women; 23–75 years old) were included in the study. Colorectal adenomas were diagnosed in 775 men and 199 women. The rate of advanced adenomas in males was 24.3% and in females 21.1%. A significant association between MONW and advanced colorectal adenoma was found in men (age‐adjusted odds ratio (OR) = 1.92, 95% confidence interval (CI): 1.06–3.47) but not in women (age‐adjusted OR = 1.80, 95% CI: 0.50–6.45). The findings suggest that men with MONW may have an increased risk of developing advanced colorectal adenoma whereas this does not seem true for females.