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SDCCAG8 Obesity Alleles and Reduced Weight Loss After a Lifestyle Intervention in Overweight Children and Adolescents
Author(s) -
Scherag André,
Kleber Michaela,
Boes Tanja,
Kolbe AndreeaLiliana,
Ruth Anne,
Grallert Harald,
Illig Thomas,
Heid Iris M.,
Toschke André M.,
Grau Katrine,
Sørensen Thorkild I.A.,
Hebebrand Johannes,
Hinney Anke,
Reinehr Thomas
Publication year - 2012
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2011.339
Subject(s) - overweight , obesity , medicine , single nucleotide polymorphism , genome wide association study , genotyping , weight loss , allele , childhood obesity , genotype , genetics , biology , gene
Genome‐wide association analyses (GWAS) contributed to the detection of a number of single‐nucleotide polymorphisms (SNPs) associated with obesity. However, little is known about the impact of the obesity‐risk alleles on weight loss‐related phenotypes after lifestyle interventions. A recent meta‐analysis of GWAS reported five genomic loci near or in the genes FTO, MC4R, TMEM18, SDCCAG8, TNKS/MSRA that were associated with obesity in children and adolescents. Here, we analyzed the effect of the 10 SNPs representative of the five loci on measures of weight loss and cardiometabolic risk after a 1‐year lifestyle intervention in 401 children and adolescents (mean age 10.74 years; 55.4% female; mean BMI 27.42 kg/m 2 , mean BMI‐standard deviation score (SDS) 2.37). For confirmation of one locus genotyping of three intronic SNPs in SDCCAG8 was performed in 626 obese adults who completed the 10‐week hypoenergetic diet program. Intronic variants of SDCCAG8 , which are associated with early onset obesity, are associated with reduced weight loss after a 1‐year lifestyle intervention in overweight children and adolescents even after adjusting for age, sex, baseline measurement, or multiple testing (all P < 10 −6 ). However, our results could not be confirmed in 626 obese adults undertaking a hypoenergetic diet intervention.