Premium
Evaluation of Specific Metabolic Rates of Major Organs and Tissues: Comparison Between Nonobese and Obese Women
Author(s) -
Wang ZiMian,
Ying Zhiliang,
BosyWestphal Anja,
Zhang Junyi,
Heller Martin,
Later Wiebke,
Heymsfield Steven B.,
Müller Manfred J.
Publication year - 2012
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2011.256
Subject(s) - adipose tissue , medicine , endocrinology , obesity , confidence interval , skeletal muscle , body mass index
Elia (1992) identified the specific resting metabolic rates ( K i ) of major organs and tissues in young adults with normal weight: 200 for liver, 240 for brain, 440 for heart and kidneys, 13 for skeletal muscle, 4.5 for adipose tissue and 12 for residual mass (all units in kcal/kg per day). The aim of the present study was to assess the applicability of Elia's K i values for obese adults. A sample of young women ( n = 80) was divided into two groups, nonobese (BMI <29.9 kg/m 2 ) and obese (BMI 30.0–43.2 kg/m 2 ). This study was based on the mechanistic model: REE = σ ( K i × T i ), where REE is whole‐body resting energy expenditure measured by indirect calorimetry and T i is the mass of individual organs and tissues measured by magnetic resonance imaging. For each organ/tissue, the corresponding Elia's K i value was analyzed respectively for nonobese and obese groups by using stepwise univariate regression analysis. Elia's K i values were within the range of 95% confidence intervals (CIs) in the nonobese group. However, Elia's K i values were outside the right boundaries of 95% CIs in the obese group and a corresponding obesity‐adjusted coefficient was calculated as 0.98, indicating that Elia's values overestimate K i by 2.0% in obese adults. Obesity‐adjusted K i values were 196 for liver, 235 for brain, 431 for heart and kidneys, 12.7 for skeletal muscle, 4.4 for adipose tissue, and 11.8 for residual mass. In conclusion, although Elia's K i values were validated in nonobese women, obesity‐adjustments are appropriate for application in obese women.