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Toward an Early Marker of Metabolic Dysfunction: Omentin‐1 in Prepubertal Children
Author(s) -
PratsPuig Anna,
Bassols Judit,
Bargalló Eva,
MasParareda Marta,
Ribot Rosa,
SorianoRodríguez Pilar,
Berengüí Àngela,
Díaz Marta,
Zegher Francis,
Ibánez Lourdes,
LópezBermejo Abel
Publication year - 2011
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2011.198
Subject(s) - adiponectin , medicine , endocrinology , adipokine , insulin resistance , adipose tissue , obesity , metabolic syndrome , asymptomatic , diabetes mellitus
Omentin‐1 is a recently recognized adipokine primarily originating in visceral adipose tissue. We posited that circulating omentin‐1 could be an early marker of metabolic dysfunction. To this end, we examined the associations between circulating omentin‐1, body fat (bioelectric impedance), an endocrine‐metabolic profile (homeostasis model assessment for insulin resistance (HOMA IR ), serum lipids, high‐molecular‐weight (HMW) adiponectin and blood pressure (BP)) and family history of obesity and diabetes in asymptomatic prepubertal children ( n = 161; 77 boys and 84 girls; age 7 ± 1 year) with a normal distribution of height and weight. Increased circulating omentin‐1 was associated with a poorer metabolic profile, with relatively higher HOMA IR , fasting triacylglycerol, BP and familial prevalence of diabetes (all P < 0.005 to P < 0.0001), and relatively lower fraction of HMW adiponectin ( P < 0.005), whereas no relationship was found with body weight or fat or with family history of obesity. All these associations were independent of age, gender and fat mass. In conclusion, circulating omentin‐1 may become a marker of metabolic dysfunction integrating insulin sensitivity, markers of adipose‐tissue metabolism and BP as early as in prepubertal childhood.