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Overweight as a Prognostic Factor in Children With Acute Lymphoblastic Leukemia
Author(s) -
Gelelete Cristina B.,
Pereira Sandra H.,
Azevedo Alice Maria B.,
Thiago Leandro S.,
Mundim Mariana,
Land Marcelo G.P.,
Costa Elaine S.
Publication year - 2011
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2011.195
Subject(s) - overweight , medicine , cohort , obesity , lymphoblastic leukemia , chemotherapy , pediatrics , cohort study , risk factor , oncology , retrospective cohort study , leukemia
Our purpose was to investigate the prognostic impact of overweight/obesity in 5‐year event‐free survival (EFS) in a cohort of children with acute lymphoblastic leukemia (ALL). We retrospectively analyzed 181 newly diagnosed ALL children enrolled between 1990 and 2009 and treated with Berlin‐Frankfurt‐Munich (BFM) protocols. The majority of children in our cohort were <10 years‐old. Our data clearly indicated that overweight/obesity is an independent predictor of relapse risk, mainly in the intermediate‐ and high‐risk groups (HR) of children. These results could be explained by changes in the chemotherapy pharmacokinetics in overweight/obese patients and by the antiapoptotic effects in leukemic cells caused by adipocytes.