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Intraperitoneal Fat Is Associated With Thickening of the Thoracic Aorta in Individuals at High Risk for Cardiovascular Events
Author(s) -
Chughtai Haroon L.,
Morgan Timothy M.,
Hamilton Craig A.,
Charoenpanichkit Charaslak,
Ding Jingzhong,
Brinkley Tina E.,
Hundley W. Gregory
Publication year - 2011
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2011.188
Subject(s) - medicine , quartile , epicardial fat , ascending aorta , intra abdominal fat , risk factor , diabetes mellitus , abdominal aorta , endocrinology , thoracic aorta , cardiology , aorta , adipose tissue , visceral fat , insulin resistance , confidence interval
Increased intraperitoneal (IP) fat is associated with increased cardiovascular (CV) risk, but mechanisms for this increase in risk are not completely established. We performed this study to assess whether IP fat is associated with ascending aortic wall thickness (AOWT), a risk factor for CV events. Four hundred and forty‐one consecutive participants, aged 55–85 years, with risk factors for CV events underwent magnetic resonance measures of AOWT and abdominal fat (subcutaneous (SC) fat + IP fat). For the ascending aorta, mean wall thickness of the 4th quartile of the IP fat was higher relative to the 1st quartile ( P ≤ 0.001). This difference persisted after accounting for SC fat ( P ≤ 0.001), as well as age, gender, height, weight, smoking, diabetes, hypertension, low‐density lipoprotein‐cholesterol (LDL‐C), high‐density lipoprotein‐cholesterol (HDL‐C), and C‐reactive protein (CRP) ( P < 0.03). Elevated IP fat volume is associated with an increase in ascending AOWT, a condition that promotes CV events in middle aged and elderly adults.