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Common Variants in FTO, MC4R, TMEM18, PRL, AIF1 , and PCSK1 Show Evidence of Association With Adult Obesity in the Greek Population
Author(s) -
Rouskas Konstantinos,
Kouvatsi Anastasia,
Paletas Konstantinos,
Papazoglou Dimitrios,
Tsapas Apostolos,
Lobbens Stéphane,
Vatin Vincent,
Durand Emmanuelle,
Labrune Yann,
Delplanque Jérôme,
Meyre David,
Froguel Philippe
Publication year - 2012
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2011.177
Subject(s) - single nucleotide polymorphism , obesity , logistic regression , odds ratio , fto gene , genetic association , demography , population , receiver operating characteristic , odds , medicine , genetics , biology , genotype , gene , sociology
Twenty‐four single‐nucleotide polymorphisms (SNPs) have been reproducibly associated with obesity. We performed a follow‐up study for obesity in the Greek adult population. A total of 510 obese and 469 lean adults were genotyped for 24 SNPs. We tested the association with obesity status using logistic regression and we evaluated the combined genetic risk of 24 SNPs by calculating the area under the receiver‐operating characteristic (ROC) curves. We nominally replicated the association with obesity (BMI ≥30 kg/m 2 ) of six SNPs in or near the FTO, MC4R, TMEM18, PRL, AIF1 , and PCSK1 loci (1.28 ≤ odds ratio (OR) ≤ 1.35; 0.004 ≤ P ≤ 0.043). The discrimination ability for obesity was slightly stronger ( P = 9.59 × 10 −6 ) when the genetic information of the 24 SNPs was added to nongenetic risk factors (area under the curve (AUC) = 0.722) in comparison with nongenetic factors analyzed alone (AUC = 0.685). Our data suggest that SNPs in or near the FTO, MC4R, TMEM18, PRL, AIF1 , and PCSK1 loci contribute to obesity risk in the Greek population.