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Influence of BMI on Level of Circulating Progenitor Cells
Author(s) -
Bellows Charles F.,
Zhang Yan,
Simmons Paul J.,
Khalsa Amrit S.,
Kolonin Mikhail G.
Publication year - 2011
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2010.347
Subject(s) - cd34 , progenitor cell , peripheral blood mononuclear cell , population , bone marrow , mesenchymal stem cell , medicine , stromal cell , endothelial stem cell , haematopoiesis , immunology , flow cytometry , stem cell , endocrinology , biology , pathology , microbiology and biotechnology , in vitro , biochemistry , environmental health
Obesity complicates a number of diseases through mechanisms that are poorly defined. Mobilization and recruitment of progenitor cells to pathological sites is an important factor in disease progression. Here, we analyzed the influence of obesity on the systemic circulation of CD34 + cell populations and correlated frequencies of cells displaying previously established cell marker signatures with the BMI. Comparative analysis of peripheral blood mononuclear cells (PBMC) from 12 nonobese (BMI <30 kg/m 2 ) and 14 obese (BMI >30 kg/m 2 ) disease‐free donors by flow cytometry revealed that obesity is associated with a fivefold increased frequency of circulating progenitor cells (CPC), a population consisting of hematopoietic and endothelial precursors. Our data also indicate that obesity is associated with increased frequency of circulating mesenchymal stromal progenitor cells (MSC). In contrast, the frequencies of mature endothelial cells (EC) and CD34‐bright leukocytes are unaffected by obesity. Combined, our results indicate that obesity promotes mobilization of progenitor cells, which may have clinical relevance.