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Genome‐Wide Association Study of Anthropometric Traits and Evidence of Interactions With Age and Study Year in Filipino Women
Author(s) -
CroteauChonka Damien C.,
Marvelle Amanda F.,
Lange Ethan M.,
Lee Nanette R.,
Adair Linda S.,
Lange Leslie A.,
Mohlke Karen L.
Publication year - 2011
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2010.256
Subject(s) - anthropometry , waist , genome wide association study , single nucleotide polymorphism , medicine , genetic association , body mass index , linkage disequilibrium , demography , obesity , fto gene , genetics , genotype , biology , sociology , gene
Increased values of multiple adiposity‐related anthropometric traits are important risk factors for many common complex diseases. We performed a genome‐wide association (GWA) study for four quantitative traits related to body size and adiposity (BMI, weight, waist circumference, and height) in a cohort of 1,792 adult Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). This is the first GWA study of anthropometric traits in Filipinos, a population experiencing a rapid transition into a more obesogenic environment. In addition to identifying suggestive evidence of additional single‐nucleotide polymorphism (SNP) association signals ( P < 10 −5 ), we replicated ( P < 0.05, same direction of additive effect) associations previously reported in European populations of both BMI and weight with MC4R and FTO , of BMI with BDNF , and of height with EFEMP1, ZBTB38 , and NPPC , but none with waist circumference. We also replicated loci reported in Japanese or Korean populations as associated with BMI ( OTOL1 ) and height ( HIST1H1PS2, C14orf145, GPC5 ). A difference in local linkage disequilibrium (LD) between European and Asian populations suggests a narrowed association region for BDNF , while still including a proposed functional nonsynonymous amino acid substitution variant (rs6265, Val66Met). Finally, we observed significant evidence ( P < 0.0042) for age‐by‐genotype interactions influencing BMI for rs17782313 ( MC4R ) and rs9939609 ( FTO ), and for a study year‐by‐genotype interaction for rs4923461 ( BDNF ). Our results show that several genetic risk factors are associated with anthropometric traits in Filipinos and provide further insight into the effects of BDNF, FTO , and MC4R on BMI.