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Removal of Melatonin Receptor Type 1 Induces Insulin Resistance in the Mouse
Author(s) -
ContrerasAlcantara Susana,
Baba Kenkichi,
Tosini Gianluca
Publication year - 2010
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2010.24
Subject(s) - melatonin , insulin resistance , receptor , endocrinology , medicine , type 2 diabetes , carbohydrate metabolism , insulin , hormone , melatonin receptor , insulin receptor , obesity , biology , diabetes mellitus
The incidence of obesity, insulin resistance, and type 2 diabetes (T2D) is increasing at an alarming rate worldwide. Emerging experimental evidence suggests that the hormone melatonin plays an important role in the regulation of glucose metabolisms. In this study, we report that removal of melatonin receptor type 1 (MT1) significantly impairs the ability of mice to metabolize glucose and such inability is probably due to an increased insulin resistance in these mice. Our data suggest that MT1 receptors are implicated in the pathogenesis of T2D and open the door for a detailed exploration on the mechanisms by which MT1 receptors signaling may affect glucose metabolism.