Premium Meal Fat Storage in Subcutaneous Adipose Tissue: Comparison of Pioglitazone and Glipizide Treatment of Type 2 DiabetesPremium
Author(s)
Basu Ananda,
Basu Rita,
Pattan Vishwanath,
Rizza Robert A.,
Jensen Michael D.
Publication year2010
Publication title
obesity
Resource typeJournals
Treatment of type 2 diabetes (T2DM) with pioglitazone changes abdominal fat in the opposite direction as treatment with glipizide. To determine whether these two medications affect adipose tissue meal fatty acid storage differently we studied 19 T2DM treated with either pioglitazone ( n = 8) or glipizide ( n = 11) and 11 non‐DM control subjects matched for age, BMI, abdominal and leg fat. A breakfast mixed meal containing [1‐ 14 C]triolein was given and abdominal and femoral subcutaneous (sc) adipose tissue biopsies were collected 6 and 24 h later to measure meal fatty acid storage. The portion of meal fatty acids stored in upper body sc and lower body sc adipose tissue did not differ between non‐DM and T2DM subjects either at 6 or 24 h. Likewise, meal fatty acid storage did not differ between the T2DM participants treated with pioglitazone or glipizide. We conclude that meal fatty acid storage in upper body and lower body sc adipose tissue is not abnormal in T2DM patients treated with pioglitazone or glipizide.
Subject(s)adipose tissue , biochemistry , chemistry , diabetes mellitus , endocrinology , fatty acid , glipizide , meal , medicine , pioglitazone , type 2 diabetes
Language(s)English
SCImago Journal Rank1.438
H-Index199
eISSN1930-739X
pISSN1930-7381
DOI10.1038/oby.2010.129
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