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25‐Hydroxyvitamin D Concentration Correlates With Insulin‐Sensitivity and BMI in Obesity
Author(s) -
Muscogiuri Giovanna,
Sorice Gian Pio,
Prioletta Annamaria,
Policola Caterina,
Casa Silvia,
Pontecorvi Alfredo,
Giaccari Andrea
Publication year - 2010
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2010.11
Subject(s) - medicine , endocrinology , insulin , glucose clamp technique , insulin resistance , vitamin d and neurology , obesity , parathyroid hormone , cholesterol , diabetes mellitus , body mass index , type 2 diabetes , insulin sensitivity , calcium
The prevalence of hypovitaminosis D is high among obese subjects. Further, low 25‐hydroxyvitamin D (25(OH)D) concentration has been postulated to be a risk factor for type 2 diabetes, although its relation with insulin‐sensitivity is not well investigated. Thus, we aimed to investigate the relationship between 25(OH)D concentration and insulin‐sensitivity, using the glucose clamp technique. In total, 39 subjects with no known history of diabetes mellitus were recruited. The association of 25(OH)D concentration with insulin‐sensitivity was evaluated by hyperinsulinemic euglycemic clamp. Subjects with low 25(OH)D (<50 nmol/l) had higher BMI ( P = 0.048), parathyroid hormone (PTH) ( P = 0.040), total cholesterol ( P = 0.012), low‐density lipoprotein (LDL) cholesterol ( P = 0.044), triglycerides ( P = 0.048), and lower insulin‐sensitivity as evaluated by clamp study ( P = 0.047). There was significant correlation between 25(OH)D and BMI ( r = −0.58; P = 0.01), PTH ( r = −0.44; P < 0.01), insulin‐sensitivity ( r = 0.43; P < 0.01), total ( r = −0.34; P = 0.030) and LDL ( r = −0.40; P = 0.023) (but not high‐density lipoprotein (HDL)) cholesterol, and triglycerides ( r = 0.45; P = 0.01). Multivariate analysis using 25(OH)D concentration, BMI, insulin‐sensitivity, HDL cholesterol, LDL cholesterol, total cholesterol, and triglycerides, as the cofactors was performed. BMI was found to be the most powerful predictor of 25(OH)D concentration ( r = −0.52; P < 0.01), whereas insulin‐sensitivity was not significant. Our study suggested that there is no cause–effect relationship between vitamin D and insulin‐sensitivity. In obesity, both low 25(OH)D concentration and insulin‐resistance appear to be dependent on the increased body size.