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Investigation of the Locus Near MC4R With Childhood Obesity in Americans of European and African Ancestry
Author(s) -
Grant Struan F.A.,
Bradfield Jonathan P.,
Zhang Haitao,
Wang Kai,
Kim Cecilia E.,
Annaiah Kiran,
Santa Erin,
Glessner Joseph T.,
Thomas Kelly,
Garris Maria,
Frackelton Edward C.,
Otieno F. George,
Shaner Julie L.,
Smith Ryan M.,
Imielinski Marcin,
Chiavacci Rosetta M.,
Li Mingyao,
Berkowitz Robert I.,
Hakonarson Hakon
Publication year - 2009
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2009.53
Subject(s) - single nucleotide polymorphism , genome wide association study , locus (genetics) , percentile , cohort , obesity , medicine , childhood obesity , snp , odds ratio , genetic association , genetics , demography , overweight , genotype , biology , gene , statistics , mathematics , sociology
Recently a modest, but consistently, replicated association was demonstrated between obesity and the single‐nucleotide polymorphism (SNP), rs17782313, 3′ of the MC4R locus as a consequence of a meta‐analysis of genome‐wide association (GWA) studies of the disease in white populations. We investigated the association in the context of the childhood form of the disease utilizing data from our ongoing GWA study in a cohort of 728 European‐American (EA) obese children (BMI ≥95th percentile) and 3,960 EA controls (BMI <95th percentile), as well as 1,008 African‐American (AA) obese children and 2,715 AA controls. rs571312, rs10871777, and rs476828 (perfect surrogates for rs17782313) yielded odds ratios in the EA cohort of 1.142 ( P = 0.045), 1.137 ( P = 0.054), and 1.145 ( P = 0.042); however, there was no significant association with these SNPs in the AA cohort. When investigating all 30 SNPs present on the Illumina BeadChip at this locus, again there was no evidence for association in AA cases when correcting for the number of tests employed. As such, variants 3′ to the MC4R locus present on the genotyping platform utilized confer a similar magnitude of risk of obesity in white children as to their adult white counterparts but this observation did not extend to AAs.