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Reciprocal Contribution of Pentraxin 3 and C‐Reactive Protein to Obesity and Metabolic Syndrome
Author(s) -
Ogawa Tsuneo,
Kawano Yurika,
Imamura Takuroh,
Kawakita Kumiko,
Sagara Mina,
Matsuo Takeshi,
Kakitsubata Yousuke,
Ishikawa Tadashi,
Kitamura Kazuo,
Hatakeyama Kinta,
Asada Yujiro,
Kodama Tatsuhiko
Publication year - 2010
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2009.507
Subject(s) - ptx3 , medicine , adiponectin , endocrinology , metabolic syndrome , c reactive protein , waist , obesity , triglyceride , pathogenesis , acute phase protein , inflammation , cholesterol , insulin resistance
Pentraxin 3 (PTX3) is an acute‐phase protein that shares structural homology with C‐reactive protein (CRP). PTX3 is produced in macrophages, endothelial cells, and adipocytes in response to inflammatory stimuli, whereas hepatocytes are the main source of CRP. Because obesity and metabolic syndrome (MetS) are considered chronic inflammatory states, PTX3 might be involved in the pathogenesis of obesity and MetS as well as CRP. Levels of CRP correlated positively with body weight, BMI, waist circumference (WC), fasting plasma glucose and interleukin (IL)‐6, and negatively with high‐density lipoprotein cholesterol and adiponectin in healthy males. In contrast, PTX3 correlated positively with adiponectin, and negatively with body weight, BMI, WC, and triglyceride. Plasma CRP significantly increased, whereas plasma PTX3 significantly decreased with increasing BMI. Plasma CRP and PTX3 levels were significantly higher and lower, respectively, in individuals who had more than one MetS component compared with those who had none. In conclusion, PTX3 and CRP antagonistically participate in the development of obesity or MetS.