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Visceral and Subcutaneous Adiposity and Adiponectin in Middle‐aged Japanese Men: The ERA JUMP Study
Author(s) -
Nakamura Yasuyuki,
Sekikawa Akira,
Kadowaki Takashi,
Kadota Aya,
Kadowaki Sayaka,
Maegawa Hiroshi,
Kita Yoshikuni,
Evans Rhobert W.,
Edmundowicz Daniel,
Curb J. David,
Ueshima Hirotsugu
Publication year - 2009
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2009.3
Subject(s) - adiponectin , medicine , obesity , adipose tissue , endocrinology , subcutaneous fat , subcutaneous adipose tissue , insulin resistance
Adiponectin is reduced in obesity and has been suggested to play an important role in modulation of atherosclerosis. We studied the relationship between visceral (VAT) and subcutaneous (SAT) adipose tissue and serum adiponectin concentrations in Japanese men. Participants were 304 randomly selected community‐based Japanese men aged 40–49 without a prior history of cardiovascular disease. Participants were grouped according to tertiles of serum adiponectin. In multiple linear regression analysis including age, pack years of smoking, and alcohol intake as covariates, log‐transformed adiponectin was inversely associated with both VAT and SAT when these two obesity measures were included separately in the models. However, log‐transformed adiponectin was inversely associated with VAT (standardized β estimate = −0.465; P < 0.0001) and positively associated with SAT (standardized β estimate = 1.277; P = 0.03), when these were included concomitantly in the model. In conclusion, VAT and SAT had differential associations with serum adiponectin concentrations.