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Plasma MR‐proADM Correlates to BMI and Decreases in Relation to Leptin After Gastric Bypass Surgery
Author(s) -
Vila Greisa,
Riedl Michaela,
Maier Christina,
Struck Joachim,
Morgenthaler Nils G.,
Handisurya Ammon,
Prager Gerhard,
Ludvik Bernhard,
Clodi Martin,
Luger Anton
Publication year - 2009
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2009.22
Subject(s) - medicine , endocrinology , leptin , adipokine , obesity , adipose tissue , adiponectin , cohort , insulin resistance
Adrenomedullin (ADM) is a vasoactive peptide found to be related to obesity and its comorbidities: type 2 diabetes, hypertension, atherosclerosis, and coronary heart disease. ADM is increased both in plasma and in adipose tissue of obese individuals when compared to lean subjects and is considered as a member of the adipokine family. We determined plasma midregional proadrenomedullin (MR‐proADM) concentrations in a cohort of 357 subjects with BMI ranging from 17.5 to 42.3 kg/m 2 and no additional medical history. In parallel, 28 severely obese patients scheduled to undergo laparoscopic Roux‐en‐Y gastric bypass (RYGB) surgery were studied at two time points: before and 1 year after surgery. Outcome measurements were: MR‐proADM, cortisol, leptin, C‐reactive protein (CRP) thyroid‐stimulating hormone (TSH), creatinine and metabolic parameters. BMI correlated significantly to plasma MR‐proADM levels ( r = 0.714, P < 0.001), also after adjustment for age and gender ( r = 0.767, P < 0.001). In obese subjects, there was a positive relationship between MR‐proADM and leptin ( r = 0.511, P = 0.006). Following RYGB, plasma MR‐proADM decreased from 0.76 ± 0.03 to 0.62 ± 0.02 pg/ml ( P < 0.0001). RYGB‐induced changes in MR‐proADM correlated significantly to changes in leptin ( r = 0.533, P = 0.004) and in CRP ( r = 0.429, P = 0.023). We conclude that BMI is an independent predictor of circulating MR‐proADM levels. Weight loss after RYGB is associated with a significant decrease in plasma MR‐proADM, which is related to surgery‐induced changes in both circulating leptin and systemic inflammation.