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Health Outcomes of Gastric Bypass Patients Compared to Nonsurgical, Nonintervened Severely Obese
Author(s) -
Adams Ted D.,
Pendleton Robert C.,
Strong Michael B.,
Kolotkin Ronette L.,
Walker James M.,
Litwin E. Sheldon,
Berjaoui Wael K.,
LaMonte Michael J.,
Cloward Tom V.,
Avelar Erick,
Owan Theophilus E.,
Nuttall Robert T.,
Gress Richard E.,
Crosby Ross D.,
Hopkins Paul N.,
Brinton Eliot A.,
Rosamond Wayne D.,
Wiebke Gail A.,
Yanowitz Frank G.,
Farney Robert J.,
Halverson R. Chad,
Simper Steven C.,
Smith Sherman C.,
Hunt Steven C.
Publication year - 2010
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2009.178
Subject(s) - medicine , weight loss , dyslipidemia , obesity , blood pressure , diabetes mellitus , gastric bypass surgery , population , obstructive sleep apnea , surgery , gastric bypass , endocrinology , environmental health
Favorable health outcomes at 2 years postbariatric surgery have been reported. With exception of the Swedish Obesity Subjects (SOS) study, these studies have been surgical case series, comparison of surgery types, or surgery patients compared to subjects enrolled in planned nonsurgical intervention. This study measured gastric bypass effectiveness when compared to two separate severely obese groups not participating in designed weight‐loss intervention. Three groups of severely obese subjects ( N = 1,156, BMI ≥ 35 kg/m 2 ) were studied: gastric bypass subjects ( n = 420), subjects seeking gastric bypass but did not have surgery ( n = 415), and population‐based subjects not seeking surgery ( n = 321). Participants were studied at baseline and 2 years. Quantitative outcome measures as well as prevalence, incidence, and resolution rates of categorical health outcome variables were determined. All quantitative variables (BMI, blood pressure, lipids, diabetes‐related variables, resting metabolic rate (RMR), sleep apnea, and health‐related quality of life) improved significantly in the gastric bypass group compared with each comparative group (all P < 0.0001, except for diastolic blood pressure and the short form (SF‐36) health survey mental component score at P < 0.01). Diabetes, dyslipidemia, and hypertension resolved much more frequently in the gastric bypass group than in the comparative groups (all P < 0.001). In the surgical group, beneficial changes of almost all quantitative variables correlated significantly with the decrease in BMI. We conclude that Roux‐en‐Y gastric bypass surgery when compared to severely obese groups not enrolled in planned weight‐loss intervention was highly effective for weight loss, improved health‐related quality of life, and resolution of major obesity‐associated complications measured at 2 years.