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Sustained NPY Overexpression in the PVN Results in Obesity via Temporarily Increasing Food Intake
Author(s) -
Tiesjema Birgitte,
Fleur Susanne E.,
Luijendijk Mieneke C.M.,
Adan Roger A.H.
Publication year - 2009
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2008.670
Subject(s) - neuropeptide y receptor , endocrinology , medicine , food intake , obesity , body weight , neuropeptide , receptor
Increasing neuropeptide Y (NPY) signaling in the paraventricular nucleus (PVN) by recombinant adeno‐associated virus (rAAV)‐mediated overexpression of NPY in rats, results in hyperphagia and obesity in rats. To determine the importance of hyperphagia in the observed obesity phenotype, we pair‐fed a group of AAV‐NPY‐injected rats to AAV‐control‐injected rats and compared parameters of energy balance to ad libitum fed AAV‐NPY‐injected rats. For 3 weeks, AAV‐NPY‐injected rats, received the same amount of food as ad libitum ‐fed rats injected with control rAAV They did not gain more body weight than these controls. When allowed access to food ad libitum , these AAV‐NPY‐injected rats increased food intake, which subsequently decreased when rats reached the same body weight as AAV‐NPY‐injected rats that were fed ad libitum for the entire study. These data indicate that overexpression of NPY in the PVN results in obesity by increasing food intake until a certain body weight is achieved.