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Association of the FTO rs9939609 Single Nucleotide Polymorphism With C‐reactive Protein Levels
Author(s) -
Fisher Eva,
Schulze Matthias B.,
Stefan Norbert,
Häring HansUlrich,
Döring Frank,
Joost HansGeorg,
AlHasani Hadi,
Boeing Heiner,
Pischon Tobias
Publication year - 2009
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2008.465
Subject(s) - medicine , single nucleotide polymorphism , endocrinology , allele , obesity , fto gene , confounding , locus (genetics) , genotype , c reactive protein , genetics , biology , gene , inflammation
Adipose tissue is a key factor determining C‐reactive protein (CRP) plasma levels. Variation at the fat‐mass and obesity‐associated (FTO) gene locus has been reported to be associated with increased body fat. We investigated whether the FTO rs9939609 T>A single nucleotide polymorphism might alter CRP levels in a population‐based sample of 2,415 participants from a large prospective cohort study. Genotype/phenotype relationships were studied by linear trend analysis stratified by sex. The rs9939609 A‐allele was significantly associated with CRP levels in both genders (men, +21%, P = 0.002; women, +14%, P = 0.01 per A‐allele). The association was attenuated, but remained statistically significant after additional adjustment for BMI, waist‐to‐hip ratio, and other potential confounding factors (men, +14%, P = 0.03; women, +12%, P = 0.02; per A‐allele). Similar results were obtained when subjects with CRP levels higher then 10 mg/l were excluded. Our data provide preliminary evidence that the FTO rs9939609 T>A polymorphism contributes to variation in plasma CRP levels independently of obesity indices.