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The FTO Gene Is Associated With Adulthood Obesity in the Mexican Population
Author(s) -
VillalobosComparán Marisela,
FloresDorantes M. Teresa,
VillarrealMolina M. Teresa,
RodríguezCruz Maricela,
GarcíaUlloa Ana C.,
Robles Lorena,
HuertasVázquez Adriana,
SaucedoVillarreal Nubia,
LópezAlarcón Mardia,
SánchezMuñoz Fausto,
DomínguezLópez Aarón,
GutiérrezAguilar Ruth,
Menjivar Marta,
CoralVázquez Ramón,
HernándezStengele Gabriel,
VitalReyes Victor S.,
AcuñaAlonzo Victor,
RomeroHidalgo Sandra,
RuizGómez Doris G.,
RiañoBarros Daniela,
Herrera Miguel F.,
GómezPérez Francisco J.,
Froguel Philippe,
GarcíaGarcía Eduardo,
TusiéLuna M. Teresa,
AguilarSalinas Carlos A.,
CanizalesQuinteros Samuel
Publication year - 2008
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2008.367
Subject(s) - fto gene , obesity , endocrinology , medicine , single nucleotide polymorphism , adipose tissue , population , allele , biology , gene , genotype , genetics , environmental health
Common polymorphisms in the fat mass and obesity‐associated gene ( FTO ) have shown strong association with obesity in several populations. In the present study, we explored the association of FTO gene polymorphisms with obesity and other biochemical parameters in the Mexican population. We also assessed FTO gene expression levels in adipose tissue of obese and nonobese individuals. The study comprised 788 unrelated Mexican‐Mestizo individuals and 31 subcutaneous fat tissue biopsies from lean and obese women. FTO single‐nucleotide polymorphisms (SNPs) rs9939609, rs1421085, and rs17817449 were associated with obesity, particularly with class III obesity, under both additive and dominant models ( P = 0.4 and 0.8, respectively). These associations remained significant after adjusting for admixture ( P = 0.3 and 0.00009, respectively). Moreover, risk alleles showed a nominal association with lower insulin levels and homeostasis model assessment of B‐cell function (HOMA‐B), and with higher homeostasis model assessment of insulin sensitivity (HOMA‐S) only in nonobese individuals ( P dom = 0.031, 0.023, and 0.049, respectively). FTO mRNA levels were significantly higher in subcutaneous fat tissue of class III obese individuals than in lean individuals ( P = 0.043). Risk alleles were significantly associated with higher FTO expression in the class III obesity group ( P = 0.047). In conclusion, FTO is a major risk factor for obesity (particularly class III) in the Mexican‐Mestizo population, and is upregulated in subcutaneous fat tissue of obese individuals.